Macklemore & Ryan Lewis’  “Can’t Hold Us,” featuring Ray Dalton, rises 2-1 on the Billboard Hot 100, becoming the pair’s second leader. With prior hit “Thrift Shop,” featuring Wanz, having reigned for six nonconsecutive weeks, the act is the first duo to take its first two singles to No. 1 in the Hot 100’s almost-55-year history.

(Following “Shop,” “Hold,” which is scaling pop, rhythmic and R&B/hip-hop formats, debuted the same week as the twosome’s “Same Love,” featuring Mary Lambert, which is being promoted only to alternative radio. “Love,” which, like the other two songs, is from the duo’s debut album “The Heist,” lifts 30-26 on Alternative and 94-83 on the Hot 100 this week.)

Among all artists, Macklemore & Lewis is the first act to send its first two charted Hot 100 singles to No. 1 since Lady Gaga arrived with “Just Dance” (three weeks on top) and “Poker Face” (one) in 2009. Bruno Mars, meanwhile, ruled with his first two entries as a lead act (“Just the Way You Are,” “Grenade”) in 2010-11 after he’d spent two weeks at No. 1 in his first visit as a featured artist on B.o.B’s “Nothin’ On You” and then peaked at No. 4 as a guest vocalist on Travie McCoy’s “Billionaire” in 2010.

“Hold” hits No. 1 on the Hot 100 fueled in part by logging a second week atop the Hot Digital Songs chart, increasing by 1% to 262,000 downloads sold, according to Nielsen SoundScan. It leads the subscription services-based On-Demand Songs survey for a third frame; remains bulleted at No. 2 on Streaming Songs (on which “Shop” reigns for a seventh week), garnering 6.1 million streams (up 6%), according to Nielsen BDS; and rises 6-5 on Hot 100 Airplay (111 million all-format audience impressions, up 19%, according to BDS).

“Hold” also racks a third week at No. 1 on Hot R&B/Hip-Hop Songs.

The track crowns the Hot 100 by dethroning P!nk’s “Just Give Me a Reason,” featuring fun.’s Nate Ruess, after three weeks. (“Hold” increases by 6% in overall Hot 100 points, while “Reason” declines by less than 1%.) “Reason” rises 3-2 on Hot 100 Airplay (136 million, up 8%); stays at No. 2 after leading Hot Digital Songs for four weeks (255,000, up 1%); and drops 5-6 on Streaming Songs (4.1 million, down 14%). With its latest sales frame, “Reason” passes 2 million downloads sold to date, becoming P!nk’s sixth single to reach the milestone.

Justin Timberlake’s “Mirrors” (5-3) is the Hot 100’s top Airplay Gainer for a third consecutive week. The cut lifts 5-3 on Hot 100 Airplay (119 million, up 23%), while remaining at No. 3 on Hot Digital Songs (176,000, up 1%; it slips 9-11 on Streaming Songs (3.6 million, down 10%). Its latest sales week pushes “Mirrors” past 1 million downloads sold since its release.

Rihanna’s “Stay,” featuring Mikky Ekko, dips from its No. 3 peak on the Hot 100 to No. 4, although it controls Hot 100 Airplay for a second week (136 million, up 1%). Bruno Mars’ “When I Was Your Man” rebounds 6-5 on the Hot 100 after leading the list four weeks ago.

Macklemore & Lewis’  “Shop” slides 4-6 on the Hot 100, ahead of Icona Pop’s debut hit “I Love It,” featuring Charli XCX (9-7). The track charges 14-10 on Hot 100 Airplay (63 million, up 16%); 7-6 on Hot Digital Songs (136,000, up 2%); and 23-21 on Streaming Songs (2.3 million, up 8%). It also takes over atop the Dance/Electronic Songs chart.

Imagine Dragons’ “Radioactive” climbs 10-8 on the Hot 100 (after reaching No. 7 five weeks ago). It commands Hot Rock Songs for a seventh week.

Florida Georgia Line’s “Cruise” is the Hot 100’s lone new top 10 entry, navigating 13-9 in its 36th week, tying Creed’s “Higher” (1999-2000) for the second-longest ascent to the top tier. Only Carrie Underwood’s “Before He Cheats” (38 weeks, 2006-07) took longer. “Cruise” reaches the top 10 by following a pattern similar to that of “Cheats”: drawing pop crossover success after first becoming a country hit. (“Higher,” meanwhile, won pop and adult radio support after starting at rock.) “Cruise” topped Country Airplay for three weeks in December. Since remixed with vocals by Nelly, its rises 21-18 on Mainstream Top 40 and 32-26 on Adult Top 40 this week. The track tallies a 10th nonconsecutive week at No. 1 on the airplay/sales/streaming-based Hot Country Songs chart (including the last five; its first five were in December/January at the zenith of its country airplay popularity).

Florida Georgia Line’s follow-up, “Get Your Shine On,” meanwhile, concurrently climbs 2-1 on Country Airplay. The act is the first to top Hot Country Songs and Country Airplay simultaneously with different titles since the former chart adopted its hybrid methodology in October.

Pitbull’s “Feel This Moment,” featuring Christina Aguilera, rounds out the Hot 100’s top 10, descending from its No. 8 peak to No. 10.

Also notably, while it falls just short of the Hot 100, Mariah Carey’s “#Beautiful,” featuring Miguel,” soars onto Hot 100 Airplay at No. 44. The track, which previews her 13th studio album, due this summer, starts with 31 million impressions after just two days of airplay. It should make an impressive debut on next week’s Hot 100 after its first full week of sales, along with its streaming data, are added to next week’s Hot 100 tabulation.

Check Billboardbiz tomorrow (May 9), when all rankings, including the Hot 100, Hot Digital Songs, Hot 100 Airplay, Streaming Songs and On-Demand Songs will be refreshed, as they are each Thursday. [Billboard.biz]